Incubator Accessories
Diagnostic Biosystems A20 A-12 A20 (A-12)
A20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor k B (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
Diagnostic Biosystems P27 KIP1 p27KIP1, Mitotic Inhibitor / Suppressor Protein
This antibody is specific to a protein of 27 kDa known as p27Kip1, a cell cycle regulatory mitotic inhibitor. Its epitope spans between aa 83-204 of p27. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Down regulation of p27Kip1 is found in many types of cancer, and decreased expression of p27Kip1 is associated with poor prognosis in several tumors, including lung, breast, colorectal and prostate.
Diagnostic Biosystems MESOTHELIN Mesothelin
Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein, which is present on the surface of normalmesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignantmesotheliomas.
Diagnostic Biosystems CADHERIN 17 Cadherin 17
Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine, colon, liver, and pancreatic ducts. It has been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused
Diagnostic Biosystems IMMUNOHISTO-SEALER ImmunoHisto-Sealer™
ImmunoHisto-Sealer™ is a preservation solution that acts as a sealant to improve tissue morphology and stain over an extended period of time. When applied to the stained section, specimens can be permanently mounted without chromogens fading. Additional benefits of the ImmunoHisto-Sealer™ include: saves hands on time when mounting slides, avoids the use of toxic chemicals such as xylene and eliminates accumulation of hazardous waste.\n\nThis product is designed for tissue specimens stained with peroxidase, alkaline phosphatase-based systems and various chromogens. After treating with ImmunoHisto-Sealer, water solution chromogens can be mounted in Permanent Mounting Media.
Diagnostic Biosystems MOUSE HRP KIT UnoVue™ Mouse HRP Kit
The UnoVue Plus Mouse HRP/DAB Detection System is a polymer-based 1-step horseradish peroxidase-labeled detection system for immunohistochemistry. This kit can detect mouse IgG and IgM antibodies, with significantly lower background than biotin/avidin detection systems. The Mouse UnoVue Plus HRP/DAB Detection System can be used for manual staining or with any automated staining instrument. The working solution of Stable DAB/Plus is stable for a week, offering convenience and cost savings due to less hazardous waste generation. This species-specific detection system is particularly useful for multiplex immunohistochemical staining assays.\nKit Contents: Peroxidase Block, Anti-Mouse HRP Polymer, Stable DAB/Plus Buffer, Stable DAB/Plus Chromogen, and an empty mixing bottle for Stable DAB/Plus.
Diagnostic Biosystems MOUSE ON MOUSE MOM UNOVUE HRP MOUSE ON MOUSE MOM UNOVUE HRP
Mouse on Mouse (MOM) Blocking Reagent is a unique serum-free blocking solution used to reduce nonspecific background staining from mouse antibodies. This blocking reagent has been shown to be more superior than serum-based blocking solutions.\n\nBlock nonspecific background staining observed during immunostaining using mouse antibodies on mouse tissue.
Diagnostic Biosystems SYNAPTOPHYSIN SYP02 Synaptophysin (SYP02)
This antibody isspecific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.
Diagnostic Biosystems SALL4 SALL4 (6E3)
Sal-like protein 4 (SALL4) is a zinc-finger transcription factor that serves as a master regulator of embryonic pluripotency and is involved in processes associated with stem cell activities. SALL4 expression in germ cells makes it a useful marker for germ cell tumors such as seminoma, embryonal carcinoma, yolk sac tumors and teratomas. SALL4 expression is also seen in the spermatogonia of normal testis.
Diagnostic Biosystems DAB AUTO DAB Auto
DAB, a widely used chromogen for immunoperoxidase staining, is well accepted among pathologists because of its increased sensitivity and ability to give cleaner background as compared to amino ethylcarbazole (AEC). Specimens stained in DAB can be dehydrated, cleared, and mounted for permanent record keeping.
Uline Additional Shelf For Slimline
Additional Shelf For Slimline Flammable Storage Cabinets - 12 And 22 Gallon
World Precision Instrument Replacement Input Kit for PicoPumps
Accessories for the popular microinjection PicoPumps
This kit includes 10' of hard tubing, and NPT fitting and a vacuum fitting, which may be used with the WPI PicoPumps that are so popular for microinjection.
